AFC Championship Betting: Manning Brothers Assemble, Bills vs Chiefs, Odds, Picks and Predictions
The 2025 AFC Championship Game is set, and it's sure to be a rematch for the ages. The Kansas City Chiefs will host the Buffalo Bills, with a trip to Super Bowl LIX on the line. And for the first time ever, two Manning brothers will be on opposite sidelines as quarterbacks Peyton and Eli Manning will serve as honorary captains for the Bills and Chiefs, respectively.
The Chiefs are the two-point favorites in the latest Chiefs vs. Bills odds from SportsLine, while the over/under for total points scored is up to 48.5. The Bills are +106 underdogs, while the Chiefs are -129 favorites.
Before making any Chiefs vs. Bills picks, NFL bets or NFL playoff predictions, make sure you check out what SportsLine NFL expert Larry Hartstein has to say. A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus.
Chiefs vs. Bills Odds, Picks and Predictions
Chiefs vs. Bills spread: Kansas City -2
Chiefs vs. Bills over/under: 48.5 points
Chiefs vs. Bills money line: Buffalo +106, Kansas City -129
BUF: Bills are 10-4 against the spread in their last 14 games
KC: Chiefs are on a 12-game home winning streak
Chiefs vs. Bills picks: See picks at SportsLine
Chiefs vs. Bills streaming: Paramount+ (Try for free)
Top Chiefs vs. Bills Predictions
For Bills vs. Chiefs in the AFC Championship Game 2025, Hartstein is leaning over on the point total. Kansas City's offense hasn't been as typically dominant throughout the season, but quarterback Patrick Mahomes and tight end Travis Kelce continue to make plays when they're needed most.
The Bills ranked second in the NFL in scoring this season thanks to NFL MVP frontrunner Josh Allen, and the team executes at a high level in high-leverage situations. Buffalo ranked seventh in third-down conversion rate (44.1%), second in fourth-down conversion rate (72.7%) and second in red-zone touchdown percentage (71.6%).
How to make Bills vs. Chiefs Picks
Hartstein has analyzed Chiefs vs. Bills from every possible angle and while have told you he's leaning over on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread.
Head to SportsLine to see what it is, and find out which team to back, now.
Who wins Bills vs. Chiefs on Sunday, and which critical x-factor makes one side of the spread hit hard?
Visit SportsLine now to see which side of the Bills vs. Chiefs spread you need to jump on, all from the expert who is 30-16 on picks involving the Chiefs , and find out, and don't forget to unlock AI props, Vegas expert picks, DFS Optimizer lineups, and all the other tools to crush your picks at SportsLine.